The 21st Annual Mayo Clinic Hematology Review, taking place on January 27, 2024, in Bloomington, Minnesota at the Radisson Blu Mall of America, is a one-day program dedicated to hematology and oncology. This event is designed for clinicians, nurses, nurse practitioners, and physician assistants. It offers a comprehensive overview of the latest advances in the treatment of various hematologic malignancies, with updates on practice guidelines informed by recent meetings, publications, and abstracts. The program features speakers discussing topics of current clinical relevance in the hematology/oncology field.